Mesenchymal Stem Cells Mediate Disk Regeneration by Suppression of Fibrosis in Nucleus Pulposus
نویسندگان
چکیده
منابع مشابه
Influence of simvastatin on the biological behavior of nucleus pulposus-derived mesenchymal stem cells
Objective(s): This research is to study the influences of different concentrations of simvastatin on the biological activities of nucleus pulposus-derived mesenchymal stem cells (NPMSC).Materials and Methods: NPMSC were cultured with different concentrations of simvastatin (0, 0.01, 0.1, and 1 μM) and assessed to determine the possible e...
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Intervertebral disc (IVD) degeneration accounts for most cases of low back pain, which usually starts from the inner nucleus pulposus (NP) area. Increasing investigation into NP regeneration highlights mesenchymal stem cells (MSC) as a potential stem cell source to repopulate the damaged and dehydrated NP. Despite the majority of researches investigate the role of MSC derived from bone marrow, ...
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Objective Excessive apoptosis of nucleus pulposus cells (NPCs) induced by various stresses, including compression, contributes to the development of intervertebral disc degeneration (IVDD). Mesenchymal stem cells (MSCs) can benefit the regeneration of NPCs and delay IVDD, but the underlying molecular mechanism is poorly understood. This study aimed to evaluate the antiapoptosis effects of bone ...
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BACKGROUND Our goal is to optimize stem cell-based tissue engineering strategies in the context of the intervertebral disc environment. We explored the benefits of co-culturing nucleus pulposus cells (NPC) and adult mesenchymal stem cells (MSC) using a novel spherical bilaminar pellet culture system where one cell type is enclosed in a sphere of the other cell type. Our 3D system provides a str...
متن کاملEffect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration
INTRODUCTION Early degenerative changes in the nucleus pulposus (NP) are observed after the disappearance of notochordal cells (NCs). Thus, it has been suggested that NCs play an important role in maintaining the NP and may have a regenerative potential on other cells of the NP. As the number of resident NP cells (NPCs) decreases in a degenerating disc, mesenchymal stromal (stem) cells (MSCs) m...
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ژورنال
عنوان ژورنال: Global Spine Journal
سال: 2012
ISSN: 2192-5682,2192-5690
DOI: 10.1055/s-0032-1318632